A Versatile and Robust Serine Protease Inhibitor Scaffold from Actinia tenebrosa

Serine proteases play pivotal roles in normal physiology and a spectrum of patho-physiological processes. Accordingly, there is considerable interest in the discovery and design of potent serine protease inhibitors for therapeutic applications. This led to concerted efforts to discover versatile and...

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Publié dans:Mar Drugs
Auteurs principaux: Chen, Xingchen, Leahy, Darren, Van Haeften, Jessica, Hartfield, Perry, Prentis, Peter J., van der Burg, Chloé A., Surm, Joachim M., Pavasovic, Ana, Madio, Bruno, Hamilton, Brett R., King, Glenn F., Undheim, Eivind A. B., Brattsand, Maria, Harris, Jonathan M.
Format: Artigo
Langue:Inglês
Publié: MDPI 2019
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Article
Accès en ligne:https://ncbi.nlm.nih.gov/pmc/articles/PMC6950308/
https://ncbi.nlm.nih.gov/pubmed/31842369
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3390/md17120701
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