Treacle controls the nucleolar response to rDNA breaks via TOPBP1 recruitment and ATR activation

Induction of DNA double-strand breaks (DSBs) in ribosomal DNA (rDNA) repeats is associated with ATM-dependent repression of ribosomal RNA synthesis and large-scale reorganization of nucleolar architecture, but the signaling events that regulate these responses are largely elusive. Here we show that...

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Publicado no:Nat Commun
Main Authors: Mooser, Clémence, Symeonidou, Ioanna-Eleni, Leimbacher, Pia-Amata, Ribeiro, Alison, Shorrocks, Ann-Marie K., Jungmichel, Stephanie, Larsen, Sara C., Knechtle, Katja, Jasrotia, Arti, Zurbriggen, Diana, Jeanrenaud, Alain, Leikauf, Colin, Fink, Daniel, Nielsen, Michael L., Blackford, Andrew N., Stucki, Manuel
Formato: Artigo
Idioma:Inglês
Publicado em: Nature Publishing Group UK 2020
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6949271/
https://ncbi.nlm.nih.gov/pubmed/31913317
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41467-019-13981-x
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