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A Ras-LSD1 axis activates PI3K signaling through PIK3IP1 suppression
PI3K Interacting Protein 1 (PIK3IP1) is a suppressor of the PI3K/Akt/mTOR pathway. We previously reported that activated Ras suppresses PIK3IP1 expression to positively regulate the PI3K pathway in cancer cells. Using doxycycline-inducible PIK3IP1, here we confirm that reversing the effect of Ras by...
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| Publicado no: | Oncogenesis |
|---|---|
| Main Authors: | , , , , |
| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
Nature Publishing Group UK
2020
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC6949251/ https://ncbi.nlm.nih.gov/pubmed/31900384 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41389-019-0185-4 |
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