Ruxolitinib Alleviates Renal Interstitial Fibrosis in UUO Mice

Ruxolitinib is a selective inhibitor of Jak1/2. Downstream signaling pathways of Jak, such as Stat3 and Akt/mTOR, are overactivated and contribute to renal interstitial fibrosis. Therefore, we explored the effect of Ruxolitinib on this pathological process. Unilateral ureteral obstruction (UUO) mode...

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Vydáno v:Int J Biol Sci
Hlavní autoři: Bai, Yu, Wang, Wei, Yin, Ping, Gao, Jian, Na, Lei, Sun, Yu, Wang, Zhuo, Zhang, Zhongbo, Zhao, Chenghai
Médium: Artigo
Jazyk:Inglês
Vydáno: Ivyspring International Publisher 2020
Témata:
Research Paper
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC6949153/
https://ncbi.nlm.nih.gov/pubmed/31929748
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.7150/ijbs.39024
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