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Ruxolitinib Alleviates Renal Interstitial Fibrosis in UUO Mice
Ruxolitinib is a selective inhibitor of Jak1/2. Downstream signaling pathways of Jak, such as Stat3 and Akt/mTOR, are overactivated and contribute to renal interstitial fibrosis. Therefore, we explored the effect of Ruxolitinib on this pathological process. Unilateral ureteral obstruction (UUO) mode...
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| Publicado no: | Int J Biol Sci |
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| Main Authors: | , , , , , , , , |
| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
Ivyspring International Publisher
2020
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC6949153/ https://ncbi.nlm.nih.gov/pubmed/31929748 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.7150/ijbs.39024 |
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