Multivariate patterning of human pluripotent cells under perfusion reveals critical roles of induced paracrine factors in kidney organoid development

Creating complex multicellular kidney organoids from pluripotent stem cells shows great promise. Further improvements in differentiation outcomes, patterning, and maturation of specific cell types are, however, intrinsically limited by standard tissue culture approaches. We describe a novel full fac...

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Publicado en:Sci Adv
Autores principales: Glass, Nick R., Takasako, Minoru, Er, Pei Xuan, Titmarsh, Drew M., Hidalgo, Alejandro, Wolvetang, Ernst J., Little, Melissa H., Cooper-White, Justin J.
Formato: Artigo
Lenguaje:Inglês
Publicado: American Association for the Advancement of Science 2020
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Research Articles
Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC6949035/
https://ncbi.nlm.nih.gov/pubmed/31934619
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1126/sciadv.aaw2746
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