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An overview and metanalysis of machine and deep learning-based CRISPR gRNA design tools

The CRISPR-Cas9 system has become the most promising and versatile tool for genetic manipulation applications. Albeit the technology has been broadly adopted by both academic and pharmaceutic societies, the activity (on-target) and specificity (off-target) of CRISPR-Cas9 are decisive factors for any...

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Библиографические подробности
Опубликовано в: :RNA Biol
Главные авторы: Wang, Jun, Zhang, Xiuqing, Cheng, Lixin, Luo, Yonglun
Формат: Artigo
Язык:Inglês
Опубликовано: Taylor & Francis 2019
Предметы:
Online-ссылка:https://ncbi.nlm.nih.gov/pmc/articles/PMC6948960/
https://ncbi.nlm.nih.gov/pubmed/31533522
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1080/15476286.2019.1669406
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