A20 as an immune tolerance factor can determine islet transplant outcomes

Islet transplantation can restore lost glycemic control in type 1 diabetes subjects but is restricted in its clinical application by a limiting supply of islets and the need for heavy immune suppression to prevent rejection. TNFAIP3, encoding the ubiquitin editing enzyme A20, regulates the activatio...

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Dades bibliogràfiques
Publicat a:JCI Insight
Autors principals: Zammit, Nathan W., Walters, Stacey N., Seeberger, Karen L., O’Connell, Philip J., Korbutt, Gregory S., Grey, Shane T.
Format: Artigo
Idioma:Inglês
Publicat: American Society for Clinical Investigation 2019
Matèries:
Research Article
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC6948770/
https://ncbi.nlm.nih.gov/pubmed/31581152
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1172/jci.insight.131028
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