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Enhancement of Antiviral CD8(+) T-Cell Responses and Complete Remission of Metastatic Melanoma in an HIV-1-Infected Subject Treated with Pembrolizumab
Background: Pembrolizumab is an immune checkpoint inhibitor against programmed cell death protein-1 (PD-1) approved for therapy in metastatic melanoma. PD-1 expression is associated with a diminished functionality in HIV-1 specific-CD8(+) T cells. It is thought that PD-1 blockade could contribute to...
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| Udgivet i: | J Clin Med |
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| Main Authors: | , , , , , , , , , , , |
| Format: | Artigo |
| Sprog: | Inglês |
| Udgivet: |
MDPI
2019
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| Fag: | |
| Online adgang: | https://ncbi.nlm.nih.gov/pmc/articles/PMC6947580/ https://ncbi.nlm.nih.gov/pubmed/31805700 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3390/jcm8122089 |
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