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Ketamine disinhibits dendrites and enhances calcium signals in prefrontal dendritic spines
A subanesthetic dose of ketamine causes acute psychotomimetic symptoms and sustained antidepressant effects. In prefrontal cortex, the prevailing disinhibition hypothesis posits that N-methyl-d-aspartate receptor (NMDAR) antagonists such as ketamine act preferentially on GABAergic neurons. However,...
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| 出版年: | Nat Commun |
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| 主要な著者: | , , , , , , |
| フォーマット: | Artigo |
| 言語: | Inglês |
| 出版事項: |
Nature Publishing Group UK
2020
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| 主題: | |
| オンライン･アクセス: | https://ncbi.nlm.nih.gov/pmc/articles/PMC6946708/ https://ncbi.nlm.nih.gov/pubmed/31911591 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41467-019-13809-8 |
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