Pharmacological polyamine catabolism upregulation with methionine salvage pathway inhibition as an effective prostate cancer therapy

Prostatic luminal epithelial cells secrete high levels of acetylated polyamines into the prostatic lumen, sensitizing them to perturbations of connected metabolic pathways. Enhanced flux is driven by spermidine/spermine N1-acetyltransferase (SSAT) activity, which acetylates polyamines leading to the...

Полное описание

Сохранить в:
Библиографические подробности
Опубликовано в: :Nat Commun
Главные авторы: Affronti, Hayley C., Rowsam, Aryn M., Pellerite, Anthony J., Rosario, Spencer R., Long, Mark D., Jacobi, Justine J., Bianchi-Smiraglia, Anna, Boerlin, Christoph S., Gillard, Bryan M., Karasik, Ellen, Foster, Barbara A., Moser, Michael, Wilton, John H., Attwood, Kristopher, Nikiforov, Mikhail A., Azabdaftari, Gissou, Pili, Roberto, Phillips, James G., Casero, Robert A., Smiraglia, Dominic J.
Формат: Artigo
Язык:Inglês
Опубликовано: Nature Publishing Group UK 2020
Предметы:
Article
Online-ссылка:https://ncbi.nlm.nih.gov/pmc/articles/PMC6946658/
https://ncbi.nlm.nih.gov/pubmed/31911608
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41467-019-13950-4
Метки: Добавить метку
Нет меток, Требуется 1-ая метка записи!

Схожие документы