Pharmacological polyamine catabolism upregulation with methionine salvage pathway inhibition as an effective prostate cancer therapy

Prostatic luminal epithelial cells secrete high levels of acetylated polyamines into the prostatic lumen, sensitizing them to perturbations of connected metabolic pathways. Enhanced flux is driven by spermidine/spermine N1-acetyltransferase (SSAT) activity, which acetylates polyamines leading to the...

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Publicado no:Nat Commun
Main Authors: Affronti, Hayley C., Rowsam, Aryn M., Pellerite, Anthony J., Rosario, Spencer R., Long, Mark D., Jacobi, Justine J., Bianchi-Smiraglia, Anna, Boerlin, Christoph S., Gillard, Bryan M., Karasik, Ellen, Foster, Barbara A., Moser, Michael, Wilton, John H., Attwood, Kristopher, Nikiforov, Mikhail A., Azabdaftari, Gissou, Pili, Roberto, Phillips, James G., Casero, Robert A., Smiraglia, Dominic J.
Formato: Artigo
Idioma:Inglês
Publicado em: Nature Publishing Group UK 2020
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6946658/
https://ncbi.nlm.nih.gov/pubmed/31911608
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41467-019-13950-4
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