COA6 Is Structurally Tuned to Function as a Thiol-Disulfide Oxidoreductase in Copper Delivery to Mitochondrial Cytochrome c Oxidase

In eukaryotes, cellular respiration is driven by mitochondrial cytochrome c oxidase (CcO), an enzyme complex that requires copper cofactors for its catalytic activity. Insertion of copper into its catalytically active subunits, including COX2, is a complex process that requires metallochaperones and...

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Detalhes bibliográficos
Publicado no:Cell Rep
Main Authors: Soma, Shivatheja, Morgada, Marcos N., Naik, Mandar T., Boulet, Aren, Roesler, Anna A., Dziuba, Nathaniel, Ghosh, Alok, Yu, Qinhong, Lindahl, Paul A., Ames, James B., Leary, Scot C., Vila, Alejandro J., Gohil, Vishal M.
Formato: Artigo
Idioma:Inglês
Publicado em: 2019
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6946597/
https://ncbi.nlm.nih.gov/pubmed/31851937
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.celrep.2019.11.054
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