HIV restriction factor APOBEC3G binds in multiple steps and conformations to search and deaminate single-stranded DNA

APOBEC3G (A3G), an enzyme expressed in primates with the potential to inhibit human immunodeficiency virus type 1 (HIV-1) infectivity, is a single-stranded DNA (ssDNA) deoxycytidine deaminase with two domains, a catalytically active, weakly ssDNA binding C-terminal domain (CTD) and a catalytically in...

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Foilsithe in:eLife
Main Authors: Morse, Michael, Naufer, M Nabuan, Feng, Yuqing, Chelico, Linda, Rouzina, Ioulia, Williams, Mark C
Formáid: Artigo
Teanga:Inglês
Foilsithe: eLife Sciences Publications, Ltd 2019
Ábhair:
Structural Biology and Molecular Biophysics
Rochtain Ar Líne:https://ncbi.nlm.nih.gov/pmc/articles/PMC6946564/
https://ncbi.nlm.nih.gov/pubmed/31850845
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.7554/eLife.52649
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