Metformin-repressed miR-381-YAP-snail axis activity disrupts NSCLC growth and metastasis

BACKGROUND: Recent evidence indicates that metformin inhibits mammalian cancer growth and metastasis through the regulation of microRNAs. Metformin regulates miR-381 stability, which plays a vital role in tumor progression. Moreover, increased YAP expression and activity induce non-small cell lung c...

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Podrobná bibliografie
Vydáno v:J Exp Clin Cancer Res
Hlavní autoři: Jin, Dan, Guo, Jiwei, Wu, Yan, Chen, Weiwei, Du, Jing, Yang, Lijuan, Wang, Xiaohong, Gong, Kaikai, Dai, Juanjuan, Miao, Shuang, Li, Xuelin, Su, Guoming
Médium: Artigo
Jazyk:Inglês
Vydáno: BioMed Central 2020
Témata:
Research
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC6945774/
https://ncbi.nlm.nih.gov/pubmed/31906986
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/s13046-019-1503-6
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