Genetic disruption of slc4a10 alters the capacity for cellular metabolism and vectorial ion transport in the choroid plexus epithelium

BACKGROUND: Genetic disruption of slc4a10, which encodes the sodium-dependent chloride/bicarbonate exchanger Ncbe, leads to a major decrease in Na(+)-dependent HCO(3)(−) import into choroid plexus epithelial cells in mice and to a marked reduction in brain intraventricular fluid volume. This suggest...

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Publicat a:Fluids Barriers CNS
Autors principals: Christensen, Inga Baasch, Wu, Qi, Bohlbro, Anders Solitander, Skals, Marianne Gerberg, Damkier, Helle Hasager, Hübner, Christian Andreas, Fenton, Robert Andrew, Praetorius, Jeppe
Format: Artigo
Idioma:Inglês
Publicat: BioMed Central 2020
Matèries:
Research
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC6945596/
https://ncbi.nlm.nih.gov/pubmed/31906971
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/s12987-019-0162-5
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