Rab8 GTPase regulates Klotho-mediated inhibition of cell growth and progression by directly modulating its surface expression in human non-small cell lung cancer

BACKGROUND: The klotho (KL) gene is an anti-aging gene that has recently been shown to also function as a general tumor suppressor. However, there is currently only limited information regarding the potential molecular signals for regulation of Klotho without identifying precise molecular mechanisms...

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Bibliographische Detailangaben
Veröffentlicht in:EBioMedicine
Hauptverfasser: Chen, Bo, Huang, Shuhong, Pisanic, II, Thomas R., Stark, Alejandro, Tao, Yong, Cheng, Bei, Li, Yue, Wei, Yunyan, Zhao, Weihong, Wang, Tza-Huei, Wu, Jianqing
Format: Artigo
Sprache:Inglês
Veröffentlicht: Elsevier 2019
Schlagworte:
Research paper
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC6945242/
https://ncbi.nlm.nih.gov/pubmed/31707148
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.ebiom.2019.10.040
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