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Advances in antibody–drug conjugates: a new era of targeted cancer therapy

Antibody–drug conjugates (ADCs), a potent class of anticancer therapeutics, comprise a high-affinity antibody (Ab) and cytotoxic payload coupled via a suitable linker for selective tumor cell killing. In the initial phase of their development, two ADCs, Mylotarg®, and Adcetris® were approved by the...

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Detalhes bibliográficos
Publicado no:Drug Discov Today
Main Authors: Sau, Samaresh, Alsaab, Hashem O., Kashaw, Sushil Kumar, Tatiparti, Katyayani, Iyer, Arun K.
Formato: Artigo
Idioma:Inglês
Publicado em: 2017
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6944323/
https://ncbi.nlm.nih.gov/pubmed/28627385
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.drudis.2017.05.011
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