m(6)A demethylase ALKBH5 inhibits pancreatic cancer tumorigenesis by decreasing WIF-1 RNA methylation and mediating Wnt signaling

BACKGROUND: Pancreatic cancer is one of the most lethal types of cancer with extremely poor diagnosis and prognosis, and chemo-resistance remains a major challenge. The dynamic and reversible N(6)-methyladenosine (m(6)A) RNA modification has emerged as a new layer of epigenetic gene regulation. METH...

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Dettagli Bibliografici
Pubblicato in:Mol Cancer
Autori principali: Tang, Bo, Yang, Yihua, Kang, Min, Wang, Yunshan, Wang, Yan, Bi, Yin, He, Songqing, Shimamoto, Fumio
Natura: Artigo
Lingua:Inglês
Pubblicazione: BioMed Central 2020
Soggetti:
Research
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC6943907/
https://ncbi.nlm.nih.gov/pubmed/31906946
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/s12943-019-1128-6
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