Sphingosine-1-Phosphate Lyase Inhibition Alters the S1P Gradient and Ameliorates Crohn’s-Like Ileitis by Suppressing Thymocyte Maturation

BACKGROUND: Lymphocytes recirculate from tissues to blood following the sphingosine-1-phosphate (S1P) gradient (low in tissues, high in blood), maintained by synthetic and degradative enzymes, among which the S1P lyase (SPL) irreversibly degrades S1P. The role of SPL in the intestine, both during ho...

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Bibliografische gegevens
Gepubliceerd in:Inflamm Bowel Dis
Hoofdauteurs: Karuppuchamy, Thangaraj, Tyler, Christopher J, Lundborg, Luke R, Pérez-Jeldres, Tamara, Kimball, Abigail K, Clambey, Eric T, Jedlicka, Paul, Rivera-Nieves, Jesús
Formaat: Artigo
Taal:Inglês
Gepubliceerd in: Oxford University Press 2020
Onderwerpen:
Basic Science Research
Online toegang:https://ncbi.nlm.nih.gov/pmc/articles/PMC6943703/
https://ncbi.nlm.nih.gov/pubmed/31807751
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/ibd/izz174
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