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Synthesis and Interaction of Fluorescent Thapsigargin Derivatives with the Sarcoplasmic Reticulum ATPase Membrane-Bound Region
Fluorescent derivatives of thapsigargin (TG) were synthesized by replacing the C(8)-butanoyl chain with a dansyl (DTG) or eosin (ETG) moiety. DTG and ETG retain the inhibitory effect of TG on the sarcoplasmic reticulum (SR) ATPase, displaying a 2 and 10 μM K(i), respectively. Steady state and lifeti...
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| Pubblicato in: | Biochemistry |
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| Autori principali: | , , , |
| Natura: | Artigo |
| Lingua: | Inglês |
| Pubblicazione: |
1995
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| Soggetti: | |
| Accesso online: | https://ncbi.nlm.nih.gov/pmc/articles/PMC6943342/ https://ncbi.nlm.nih.gov/pubmed/7536037 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/bi00015a026 |
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