Combined small molecule and loss-of-function screen uncovers estrogen receptor alpha and CAD as host factors for HDV infection and antiviral targets

OBJECTIVE: Hepatitis D virus (HDV) is a circular RNA virus coinfecting hepatocytes with hepatitis B virus. Chronic hepatitis D results in severe liver disease and an increased risk of liver cancer. Efficient therapeutic approaches against HDV are absent. DESIGN: Here, we combined an RNAi loss-of-fun...

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Detalhes bibliográficos
Publicado no:Gut
Main Authors: Verrier, Eloi R, Weiss, Amélie, Bach, Charlotte, Heydmann, Laura, Turon-Lagot, Vincent, Kopp, Arnaud, El Saghire, Houssein, Crouchet, Emilie, Pessaux, Patrick, Garcia, Thomas, Pale, Patrick, Zeisel, Mirjam B, Sureau, Camille, Schuster, Catherine, Brino, Laurent, Baumert, Thomas F
Formato: Artigo
Idioma:Inglês
Publicado em: BMJ Publishing Group 2020
Assuntos:
Hepatology
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6943243/
https://ncbi.nlm.nih.gov/pubmed/30833451
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1136/gutjnl-2018-317065
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