Potent anti‐myeloma activity of the TOPK inhibitor OTS514 in pre‐clinical models

Multiple myeloma (MM) continues to be considered incurable, necessitating new drug discovery. The mitotic kinase T‐LAK cell‐originated protein kinase/PDZ‐binding kinase (TOPK/PBK) is associated with proliferation of tumor cells, maintenance of cancer stem cells, and poor patient prognosis in many ca...

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Bibliographic Details
Published in:Cancer Med
Main Authors: Stefka, Andrew T., Johnson, David, Rosebeck, Shaun, Park, Jae‐Hyun, Nakamura, Yusuke, Jakubowiak, Andrzej J.
Format: Artigo
Language:Inglês
Published: John Wiley and Sons Inc. 2019
Subjects:
Cancer Biology
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC6943155/
https://ncbi.nlm.nih.gov/pubmed/31714026
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/cam4.2695
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