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Ubiquitin carboxyl‐terminal hydrolase L1 promotes hypoxia‐inducible factor 1‐dependent tumor cell malignancy in spheroid models

Hypoxia‐inducible factor 1 (HIF‐1) is a critical heterodimeric transcription factor for tumor malignancy. Recently, ubiquitin carboxyl‐terminal hydrolase L1 (UCHL1) has been reported to function as a deubiquitinating enzyme for the stabilization of its α subunit (HIF‐1α). In the present study, we sh...

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Detalhes bibliográficos
Publicado no:Cancer Sci
Main Authors: Li, Xuebing, Hattori, Akira, Takahashi, Senye, Goto, Yoko, Harada, Hiroshi, Kakeya, Hideaki
Formato: Artigo
Idioma:Inglês
Publicado em: John Wiley and Sons Inc. 2019
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6942421/
https://ncbi.nlm.nih.gov/pubmed/31729096
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1111/cas.14236
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