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Exploring alternative catalytic mechanisms of Cas9 HNH domain
Understanding the reaction mechanism of Cas9 is crucial for the application of programmable gene editing. Despite the availability of the structures of Cas9 in apo- and substrate-bound forms, the catalytically active structure is still unclear. Our first attempt to explore the catalytic mechanism of...
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| Publicado en: | Proteins |
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| Autores principales: | , , |
| Formato: | Artigo |
| Lenguaje: | Inglês |
| Publicado: |
2019
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| Materias: | |
| Acceso en línea: | https://ncbi.nlm.nih.gov/pmc/articles/PMC6942198/ https://ncbi.nlm.nih.gov/pubmed/31390092 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/prot.25796 |
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