The non-antibiotic macrolide EM900 attenuates HDM and poly(I:C)-induced airway inflammation with inhibition of macrophages in a mouse model

OBJECTIVE: Macrolides have been reported to reduce the exacerbation of severe asthma. The aim of this study was to clarify the effects and mechanisms of EM900, a non-antibiotic macrolide, on allergic airway inflammation. METHODS: Mice were sensitized and challenged by house dust mite (HDM), then exp...

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Udgivet i:Inflamm Res
Main Authors: Sadamatsu, Hironori, Takahashi, Koichiro, Tashiro, Hiroki, Kato, Go, Noguchi, Yoshihiko, Kurata, Keigo, Ōmura, Satoshi, Kimura, Shinya, Sunazuka, Toshiaki, Sueoka-Aragane, Naoko
Format: Artigo
Sprog:Inglês
Udgivet: Springer International Publishing 2019
Fag:
Original Research Paper
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC6942021/
https://ncbi.nlm.nih.gov/pubmed/31820024
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1007/s00011-019-01302-3
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