Metastatic Phosphatase PRL-3 Induces Ovarian Cancer Stem Cell Sub-population through Phosphatase-Independent Deacetylation Modulations

Cancer stem cells (CSCs) are responsible for tumor initiation, chemoresistance, metastasis, and relapse, but the underlying molecular origin of CSCs remains elusive. Here we identified that metastatic phosphatase of regenerating liver 3 (PRL-3) transcriptionally upregulates SOX2 in the expansion of...

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Bibliographic Details
Published in:iScience
Main Authors: Zhang, Mingming, Wei, Yanli, Liu, Yanbin, Guan, Wen, Zhang, Xiaomei, Kong, Jianqiu, Li, Hui, Yang, Shulan, Wang, Haihe
Format: Artigo
Language:Inglês
Published: Elsevier 2019
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Article
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC6941878/
https://ncbi.nlm.nih.gov/pubmed/31887658
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.isci.2019.100766
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