Dynamic Interaction of USP14 with the Chaperone HSC70 Mediates Crosstalk between the Proteasome, ER Signaling, and Autophagy

USP14 is a deubiquitinating enzyme associated with the proteasome important for protein degradation. Here we show that upon proteasome inhibition or expression of the mutant W58A-USP14, association of USP14 with the 19S regulatory particle is disrupted. MS-based interactomics revealed an interaction...

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Pubblicato in:iScience
Autori principali: Srinivasan, Vignesh, Bruelle, Celine, Scifo, Enzo, Pham, Dan Duc, Soliymani, Rabah, Lalowski, Maciej, Lindholm, Dan
Natura: Artigo
Lingua:Inglês
Pubblicazione: Elsevier 2019
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Article
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC6941875/
https://ncbi.nlm.nih.gov/pubmed/31901637
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.isci.2019.100790
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