Cell-type specific differences in antiretroviral penetration and the effects of HIV-1 Tat and morphine among primary human brain endothelial cells, astrocytes, pericytes, and microglia

The inability to achieve adequate intracellular antiretroviral concentrations may contribute to HIV persistence within the brain and to neurocognitive deficits in opioid abusers. To investigate, intracellular antiretroviral concentrations were measured in primary human astrocytes, microglia, pericyt...

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Gepubliceerd in:Neurosci Lett
Hoofdauteurs: Patel, Sulay H., Ismaiel, Omnia A., Mylott, William R., Yuan, Moucun, McClay, Joseph L., Paris, Jason J., Hauser, Kurt F., McRae, MaryPeace
Formaat: Artigo
Taal:Inglês
Gepubliceerd in: 2019
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Article
Online toegang:https://ncbi.nlm.nih.gov/pmc/articles/PMC6941658/
https://ncbi.nlm.nih.gov/pubmed/31491466
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.neulet.2019.134475
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