An Early mtUPR: Redistribution of the Nuclear Transcription Factor Rox1 to Mitochondria Protects against Intramitochondrial Proteotoxic Aggregates

The mitochondrial proteome is built mainly by import of nuclear-encoded precursors, which are targeted mostly by cleavable presequences. Presequence processing upon import is essential for proteostasis and survival, but the consequences of dysfunctional protein maturation are unknown. We find that i...

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Publicado en:Mol Cell
Autores principales: Poveda-Huertes, Daniel, Matic, Stanka, Marada, Adinarayana, Habernig, Lukas, Licheva, Mariya, Myketin, Lisa, Gilsbach, Ralf, Tosal-Castano, Sergi, Papinski, Daniel, Mulica, Patrycja, Kretz, Oliver, Kücükköse, Cansu, Taskin, Asli Aras, Hein, Lutz, Kraft, Claudine, Büttner, Sabrina, Meisinger, Chris, Vögtle, F.-Nora
Formato: Artigo
Lenguaje:Inglês
Publicado: Cell Press 2020
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Article
Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC6941230/
https://ncbi.nlm.nih.gov/pubmed/31630969
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.molcel.2019.09.026
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