Reconstitution of the Human Nigro-striatal Pathway on-a-Chip Reveals OPA1-Dependent Mitochondrial Defects and Loss of Dopaminergic Synapses

Stem cell-derived neurons are generally obtained in mass cultures that lack both spatial organization and any meaningful connectivity. We implement a microfluidic system for long-term culture of human neurons with patterned projections and synaptic terminals. Co-culture of human midbrain dopaminergi...

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Veröffentlicht in:Cell Rep
Hauptverfasser: Iannielli, Angelo, Ugolini, Giovanni Stefano, Cordiglieri, Chiara, Bido, Simone, Rubio, Alicia, Colasante, Gaia, Valtorta, Marco, Cabassi, Tommaso, Rasponi, Marco, Broccoli, Vania
Format: Artigo
Sprache:Inglês
Veröffentlicht: Cell Press 2019
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Article
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC6941223/
https://ncbi.nlm.nih.gov/pubmed/31875567
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.celrep.2019.11.111
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