Loss of p53 Sensitizes Cells to Palmitic Acid-Induced Apoptosis by Reactive Oxygen Species Accumulation

Palmitic acid, the most common saturated free fatty acid, can lead to lipotoxicity and apoptosis when overloaded in non-fat cells. Palmitic acid accumulation can induce pancreatic β-cell dysfunction and cardiac myocyte apoptosis. Under various cellular stresses, the activation of p53 signaling can l...

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Publicado no:Int J Mol Sci
Main Authors: Yu, Guowu, Luo, Hongwei, Zhang, Na, Wang, Yongbin, Li, Yangping, Huang, Huanhuan, Liu, Yinghong, Hu, Yufeng, Liu, Hanmei, Zhang, Junjie, Tang, Yi, Huang, Yubi
Formato: Artigo
Idioma:Inglês
Publicado em: MDPI 2019
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6941153/
https://ncbi.nlm.nih.gov/pubmed/31842349
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3390/ijms20246268
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