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Vortioxetine Subchronically Activates Serotonergic Transmission via Desensitization of Serotonin 5-HT(1A) Receptor with 5-HT(3) Receptor Inhibition in Rats
Vortioxetine is a novel, multimodal antidepressant with unique targets, including the inhibition of the serotonin transporter (SET), of serotonin 5-HT(3) (5-HT3R), and of 5-HT(7) (5-HT7R) receptors and partial agonism to serotonin 5-HT(1A) (5-HT1AR) receptors in humans. Vortioxetine has a lower affi...
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| Publicat a: | Int J Mol Sci |
|---|---|
| Autors principals: | , , |
| Format: | Artigo |
| Idioma: | Inglês |
| Publicat: |
MDPI
2019
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| Matèries: | |
| Accés en línia: | https://ncbi.nlm.nih.gov/pmc/articles/PMC6940928/ https://ncbi.nlm.nih.gov/pubmed/31835640 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3390/ijms20246235 |
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