Siplizumab selectively depletes effector memory T-cells and promotes a relative expansion of alloreactive regulatory T-cells in vitro

Siplizumab, a humanized anti-CD2 monoclonal antibody, has been used in conditioning regimens for hematopoietic cell transplantation and tolerance induction with combined kidney-bone marrow transplantation. Siplizumab-based tolerance induction regimens deplete T cells globally while enriching regulat...

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Veröffentlicht in:Am J Transplant
Hauptverfasser: Podestà, Manuel Alfredo, Binder, Christian, Sellberg, Felix, DeWolf, Susan, Shonts, Brittany, Ho, Siu-Hong, Obradovic, Aleksandar, Waffarn, Elizabeth, Danzl, Nichole, Berglund, David, Sykes, Megan
Format: Artigo
Sprache:Inglês
Veröffentlicht: 2019
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Article
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC6940533/
https://ncbi.nlm.nih.gov/pubmed/31319439
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1111/ajt.15533
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