UPR(ER) promotes lipophagy independent of chaperones to extend life span

Longevity is dictated by a combination of environmental and genetic factors. One of the key mechanisms to regulate life-span extension is the induction of protein chaperones for protein homeostasis. Ectopic activation of the unfolded protein response of the endoplasmic reticulum (UPR(ER)) specifical...

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Veröffentlicht in:Sci Adv
Hauptverfasser: Daniele, Joseph R., Higuchi-Sanabria, Ryo, Durieux, Jenni, Monshietehadi, Samira, Ramachandran, Vidhya, Tronnes, Sarah U., Kelet, Naame, Sanchez, Melissa, Metcalf, Melissa G., Garcia, Gilberto, Frankino, Phillip A., Benitez, Camila, Zeng, Mandy, Esping, Daniel J., Joe, Larry, Dillin, Andrew
Format: Artigo
Sprache:Inglês
Veröffentlicht: American Association for the Advancement of Science 2020
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Research Articles
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC6938708/
https://ncbi.nlm.nih.gov/pubmed/31911951
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1126/sciadv.aaz1441
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