High CO(2) Downregulates Skeletal Muscle Protein Anabolism via AMP-activated Protein Kinase α2–mediated Depressed Ribosomal Biogenesis

High CO(2) retention, or hypercapnia, is associated with worse outcomes in patients with chronic pulmonary diseases. Skeletal muscle wasting is also an independent predictor of poor outcomes in patients with acute and chronic pulmonary diseases. Although previous evidence indicates that high CO(2) a...

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Publicado en:Am J Respir Cell Mol Biol
Main Authors: Korponay, Tanner C., Balnis, Joseph, Vincent, Catherine E., Singer, Diane V., Chopra, Amit, Adam, Alejandro P., Ginnan, Roman, Singer, Harold A., Jaitovich, Ariel
Formato: Artigo
Idioma:Inglês
Publicado: American Thoracic Society 2020
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Original Research
Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC6938128/
https://ncbi.nlm.nih.gov/pubmed/31264907
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1165/rcmb.2019-0061OC
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