Lasting s-ketamine block of spreading depolarizations in subarachnoid hemorrhage: a retrospective cohort study

OBJECTIVE: Spreading depolarizations (SD) are characterized by breakdown of transmembrane ion gradients and excitotoxicity. Experimentally, N-methyl-d-aspartate receptor (NMDAR) antagonists block a majority of SDs. In many hospitals, the NMDAR antagonist s-ketamine and the GABA(A) agonist midazolam...

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Bibliografiske detaljer
Udgivet i:Crit Care
Main Authors: Santos, Edgar, Olivares-Rivera, Arturo, Major, Sebastian, Sánchez-Porras, Renán, Uhlmann, Lorenz, Kunzmann, Kevin, Zerelles, Roland, Kentar, Modar, Kola, Vasilis, Aguilera, Adrian Hernández, Herrera, Mildred Gutierrez, Lemale, Coline L., Woitzik, Johannes, Hartings, Jed A., Sakowitz, Oliver W., Unterberg, Andreas W., Dreier, Jens P.
Format: Artigo
Sprog:Inglês
Udgivet: BioMed Central 2019
Fag:
Research
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC6937792/
https://ncbi.nlm.nih.gov/pubmed/31888772
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/s13054-019-2711-3
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