Safety of switching from vitamin K antagonist to non-vitamin K antagonist oral anticoagulant in frail elderly with atrial fibrillation: rationale and design of the FRAIL-AF randomised controlled trial

INTRODUCTION: Clinical guidelines recommend non-vitamin K antagonist oral anticoagulants (NOACs) over vitamin K antagonists (VKAs) for stroke prevention in most patients with atrial fibrillation (AF). Frail elderly were under-represented in the landmark NOAC-trials, leaving a knowledge gap on the op...

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Detalhes bibliográficos
Publicado no:BMJ Open
Main Authors: Joosten, Linda P T, van Doorn, Sander, Hoes, Arno W, Nierman, Melchior C, Wiersma, Nynke M, Koek, Huiberdina L, Hemels, Martin E W, Huisman, Menno V, Roes, Kit C, van den Bor, Rutger M, Buding, Wim F, Rutten, Frans H, Geersing, Geert-Jan
Formato: Artigo
Idioma:Inglês
Publicado em: BMJ Publishing Group 2019
Assuntos:
General practice / Family practice
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6937027/
https://ncbi.nlm.nih.gov/pubmed/31888928
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1136/bmjopen-2019-032488
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