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Lower S-adenosylmethionine levels and DNA hypomethylation of placental growth factor (PlGF) in placental tissue of early-onset preeclampsia-complicated pregnancies

INTRODUCTION: The pathophysiology of preeclampsia is largely unknown. Serum placental induced growth factor (PlGF) levels are decreased during second trimester pregnancy. Aberrant DNA methylation is suggested to be involved in the etiology of preeclampsia (PE). We hypothesize that DNA methylation is...

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Detalhes bibliográficos
Publicado no:PLoS One
Main Authors: Heil, Sandra G., Herzog, Emilie M., Griffioen, Pieter H., van Zelst, Bertrand, Willemsen, Sten P., de Rijke, Yolanda B., Steegers-Theunissen, Regine P. M., Steegers, Eric A. P.
Formato: Artigo
Idioma:Inglês
Publicado em: Public Library of Science 2019
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Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6936822/
https://ncbi.nlm.nih.gov/pubmed/31887212
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0226969
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