CRISPR/Cas9-based targeted genome editing for correction of recessive dystrophic epidermolysis bullosa using iPS cells

Recessive dystrophic epidermolysis bullosa (RDEB) is a severe inherited skin disorder caused by mutations in the COL7A1 gene encoding type VII collagen (C7). The spectrum of severity depends on the type of mutation in the COL7A1 gene. C7 is the major constituent of anchoring fibrils (AFs) at the bas...

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Detalhes bibliográficos
Publicado no:Proc Natl Acad Sci U S A
Main Authors: Jacków, Joanna, Guo, Zongyou, Hansen, Corey, Abaci, Hasan E., Doucet, Yanne S., Shin, Jung U, Hayashi, Ryota, DeLorenzo, Dominick, Kabata, Yudai, Shinkuma, Satoru, Salas-Alanis, Julio C., Christiano, Angela M.
Formato: Artigo
Idioma:Inglês
Publicado em: National Academy of Sciences 2019
Assuntos:
Biological Sciences
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6936361/
https://ncbi.nlm.nih.gov/pubmed/31818947
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1907081116
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