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Revealing Dynamic Mechanisms of Cell Fate Decisions From Single-Cell Transcriptomic Data

Cell fate decisions play a pivotal role in development, but technologies for dissecting them are limited. We developed a multifunction new method, Topographer, to construct a “quantitative” Waddington’s landscape of single-cell transcriptomic data. This method is able to identify complex cell-state...

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Detalhes bibliográficos
Publicado no:Front Genet
Main Authors: Zhang, Jiajun, Nie, Qing, Zhou, Tianshou
Formato: Artigo
Idioma:Inglês
Publicado em: Frontiers Media S.A. 2019
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6935941/
https://ncbi.nlm.nih.gov/pubmed/31921315
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3389/fgene.2019.01280
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