Thyroxine Alleviates Energy Failure, Prevents Myocardial Cell Apoptosis, and Protects against Doxorubicin-Induced Cardiac Injury and Cardiac Dysfunction via the LKB1/AMPK/mTOR Axis in Mice

BACKGROUND: Previous studies have demonstrated that energy failure is closely associated with cardiac injury. Doxorubicin (DOX) is a commonly used clinical chemotherapy drug that can mediate cardiac injury through a variety of mechanisms. Thyroxine is well known to play a critical role in energy gen...

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Veröffentlicht in:Dis Markers
Hauptverfasser: Wang, Yuan, Zhu, Shan, Liu, Hongtao, Wei, Wen, Tu, Yi, Chen, Chuang, Song, Junlong, Li, Juanjuan, Sun, Shengrong, Wang, Changhua, Xu, Zhiliang
Format: Artigo
Sprache:Inglês
Veröffentlicht: Hindawi 2019
Schlagworte:
Research Article
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC6935797/
https://ncbi.nlm.nih.gov/pubmed/31929843
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1155/2019/7420196
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