Bag-1 stimulates Bad phosphorylation through activation of Akt and Raf kinases to mediate cell survival in breast cancer

BACKGROUND: Bag-1 (Bcl-2-associated athanogene) is a multifunctional anti-apoptotic protein frequently overexpressed in cancer. Bag-1 interacts with a variety of cellular targets including Hsp70/Hsc70 chaperones, Bcl-2, nuclear hormone receptors, Akt and Raf kinases. In this study, we investigated i...

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Detalhes bibliográficos
Publicado no:BMC Cancer
Main Authors: Kizilboga, Tugba, Baskale, Emine Arzu, Yildiz, Jale, Akcay, Izzet Mehmet, Zemheri, Ebru, Can, Nisan Denizce, Ozden, Can, Demir, Salih, Ezberci, Fikret, Dinler-Doganay, Gizem
Formato: Artigo
Idioma:Inglês
Publicado em: BioMed Central 2019
Assuntos:
Research Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6935482/
https://ncbi.nlm.nih.gov/pubmed/31883527
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/s12885-019-6477-4
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