High prevalence and disease correlation of autoantibodies against p40 encoded by long interspersed nuclear elements (LINE-1) in systemic lupus erythematosus

OBJECTIVE. The long interspersed nuclear element 1 (LINE-1) encodes two proteins, the RNA-binding p40 and the endonuclease and reverse transcriptase (ORF2p); both required for LINE-1 to retrotranspose. In cells expressing LINE-1, these proteins assemble with the LINE-1 RNA and additional RNA-binding...

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Опубликовано в: :Arthritis Rheumatol
Главные авторы: Carter, Victoria, LaCava, John, Taylor, Martin S., Liang, Shu Ying, Mustelin, Cecilia, Ukadike, Kennedy C., Bengtsson, Anders, Lood, Christian, Mustelin, Tomas
Формат: Artigo
Язык:Inglês
Опубликовано: 2020
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Article
Online-ссылка:https://ncbi.nlm.nih.gov/pmc/articles/PMC6935427/
https://ncbi.nlm.nih.gov/pubmed/31342656
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/art.41054
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