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Evolutionary Analysis of Bile Acid-Conjugating Enzymes Reveals a Complex Duplication and Reciprocal Loss History

To fulfill their physiological functions, bile acids are conjugated with amino acids. In humans, conjugation is catalyzed by bile acid coenzyme A: amino acid N-acyltransferase (BAAT), an enzyme with a highly conserved catalytic triad in its active site. Interestingly, the conjugated amino acids are...

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Detalhes bibliográficos
Publicado no:Genome Biol Evol
Main Authors: Kirilenko, Bogdan M, Hagey, Lee R, Barnes, Stephen, Falany, Charles N, Hiller, Michael
Formato: Artigo
Idioma:Inglês
Publicado em: Oxford University Press 2019
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6934887/
https://ncbi.nlm.nih.gov/pubmed/31670760
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/gbe/evz238
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