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Transdermal delivery of nobiletin using ionic liquids

Nobiletin (NOB), a flavonoid, has extremely low water solubility and low oral bioavailability; however, despite these problems, various physiological effects have been investigated in vitro. In the present study, we investigated the transdermal delivery of NOB using choline and geranic acid (CAGE),...

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Detalhes bibliográficos
Publicado no:Sci Rep
Main Authors: Hattori, Tadashi, Tagawa, Hiroki, Inai, Makoto, Kan, Toshiyuki, Kimura, Shin-ichiro, Itai, Shigeru, Mitragotri, Samir, Iwao, Yasunori
Formato: Artigo
Idioma:Inglês
Publicado em: Nature Publishing Group UK 2019
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6934657/
https://ncbi.nlm.nih.gov/pubmed/31882884
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41598-019-56731-1
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