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Molecular Dynamics model of peptide-protein conjugation: case study of covalent complex between Sos1 peptide and N-terminal SH3 domain from Grb2
We have investigated covalent conjugation of VPPPVPPRRRX′ peptide (where X′ denotes N(ε)-chloroacetyl lysine) to N-terminal SH3 domain from adapter protein Grb2. Our experimental results confirmed that the peptide first binds to the SH3 domain noncovalently before establishing a covalent linkage thr...
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| Publié dans: | Sci Rep |
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| Auteurs principaux: | , , , , , |
| Format: | Artigo |
| Langue: | Inglês |
| Publié: |
Nature Publishing Group UK
2019
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| Sujets: | |
| Accès en ligne: | https://ncbi.nlm.nih.gov/pmc/articles/PMC6934455/ https://ncbi.nlm.nih.gov/pubmed/31882608 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41598-019-56078-7 |
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