Absence of NKG2D ligands defines leukaemia stem cells and mediates their immune evasion

Patients with acute myeloid leukaemia (AML) often achieve remission after therapy, but sub-sequently die of relapse(1) that is driven by chemotherapy-resistant leukaemic stem cells (LSCs)(2,3). LSCs are defined by their capacity to initiate leukaemia in immunocompromised mice(4). However, this precl...

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Published in:Nature
Main Authors: Paczulla, Anna M., Rothfelder, Kathrin, Raffel, Simon, Konantz, Martina, Steinbacher, Julia, Wang, Hui, Tandler, Claudia, Mbarga, Marcelle, Schaefer, Thorsten, Falcone, Mattia, Nievergall, Eva, Dörfel, Daniela, Hanns, Pauline, Passweg, Jakob R., Lutz, Christoph, Schwaller, Juerg, Zeiser, Robert, Blazar, Bruce R., Caligiuri, Michael A., Dirnhofer, Stephan, Lundberg, Pontus, Kanz, Lothar, Quintanilla-Martinez, Leticia, Steinle, Alexander, Trumpp, Andreas, Salih, Helmut R., Lengerke, Claudia
Format: Artigo
Language:Inglês
Published: 2019
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Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC6934414/
https://ncbi.nlm.nih.gov/pubmed/31316209
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41586-019-1410-1
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