Single-Cell Profiling Defines Transcriptomic Signatures Specific to Tumor-Reactive versus Virus-Responsive CD4(+) T Cells

Most current tumor immunotherapy strategies leverage cytotoxic CD8(+) T cells. Despite evidence for clinical potential of CD4(+) tumor-infiltrating lymphocytes (TILs), their functional diversity limits our ability to harness their activity. Here, we use single-cell mRNA sequencing to analyze the res...

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Veröffentlicht in:Cell Rep
Hauptverfasser: Magen, Assaf, Nie, Jia, Ciucci, Thomas, Tamoutounour, Samira, Zhao, Yongmei, Mehta, Monika, Tran, Bao, McGavern, Dorian B., Hannenhalli, Sridhar, Bosselut, Rémy
Format: Artigo
Sprache:Inglês
Veröffentlicht: 2019
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Article
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC6934378/
https://ncbi.nlm.nih.gov/pubmed/31801070
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.celrep.2019.10.131
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