A Clostridia-rich microbiota enhances bile acid excretion in diarrhea-predominant irritable bowel syndrome

An excess of fecal bile acids (BAs) is thought to be one of the mechanisms for diarrhea-predominant irritable bowel syndrome (IBS-D). However, the factors causing excessive BA excretion remain incompletely studied. Given the importance of gut microbiota in BA metabolism, we hypothesized that gut dys...

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Gepubliceerd in:J Clin Invest
Hoofdauteurs: Zhao, Ling, Yang, Wei, Chen, Yang, Huang, Fengjie, Lu, Lin, Lin, Chengyuan, Huang, Tao, Ning, Ziwan, Zhai, Lixiang, Zhong, Linda L.D., Lam, Waiching, Yang, Zhen, Zhang, Xuan, Cheng, Chungwah, Han, Lijuan, Qiu, Qinwei, Shang, Xiaoxiao, Huang, Runyue, Xiao, Haitao, Ren, Zhenxing, Chen, Dongfeng, Sun, Silong, El-Nezami, Hani, Cai, Zongwei, Lu, Aiping, Fang, Xiaodong, Jia, Wei, Bian, Zhaoxiang
Formaat: Artigo
Taal:Inglês
Gepubliceerd in: American Society for Clinical Investigation 2019
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Research Article
Online toegang:https://ncbi.nlm.nih.gov/pmc/articles/PMC6934182/
https://ncbi.nlm.nih.gov/pubmed/31815740
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1172/JCI130976
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