Preterm neonates benefit from low prophylactic platelet transfusion threshold despite varying risk of bleeding or death

The Platelets for Neonatal Thrombocytopenia (PlaNeT-2) trial reported an unexpected overall benefit of a prophylactic platelet transfusion threshold of 25 × 10(9)/L compared with 50 × 10(9)/L for major bleeding and/or mortality in preterm neonates (7% absolute-risk reduction). However, some neonates...

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Udgivet i:Blood
Main Authors: Fustolo-Gunnink, Susanna F., Fijnvandraat, Karin, van Klaveren, David, Stanworth, Simon J., Curley, Anna, Onland, Wes, Steyerberg, Ewout W., de Kort, Ellen, d’Haens, Esther J., Hulzebos, Christian V., Huisman, Elise J., de Boode, Willem P., Lopriore, Enrico, van der Bom, Johanna G.
Format: Artigo
Sprog:Inglês
Udgivet: American Society of Hematology 2019
Fag:
Clinical Trials and Observations
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC6933290/
https://ncbi.nlm.nih.gov/pubmed/31697817
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1182/blood.2019000899
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