Functional characterization of a novel opioid, PZM21, and its effects on the behavioural responses to morphine

BACKGROUND AND PURPOSE: The concept of opioid ligands biased towards the G protein pathway with minimal recruitment of β‐arrestin‐2 is a promising approach for the development of novel, efficient, and potentially nonaddictive opioid therapeutics. A recently discovered biased μ‐opioid receptor agonis...

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Detalhes bibliográficos
Publicado no:Br J Pharmacol
Main Authors: Kudla, Lucja, Bugno, Ryszard, Skupio, Urszula, Wiktorowska, Lucja, Solecki, Wojciech, Wojtas, Adam, Golembiowska, Krystyna, Zádor, Ferenc, Benyhe, Sándor, Buda, Szymon, Makuch, Wioletta, Przewlocka, Barbara, Bojarski, Andrzej J., Przewlocki, Ryszard
Formato: Artigo
Idioma:Inglês
Publicado em: John Wiley and Sons Inc. 2019
Assuntos:
Research Papers
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6932942/
https://ncbi.nlm.nih.gov/pubmed/31347704
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1111/bph.14805
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